Nigerian Journal of Cardiology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 12  |  Issue : 1  |  Page : 23--26

Electrocardiographic characteristics of children with obstructive sleep apnea in a tertiary health center in Kano


Aliyu Ibrahim1, Abdulazeez Ahmed2,  
1 Department of Paediatrics, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria
2 Department of Ear, Nose, Throat, Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria

Correspondence Address:
Aliyu Ibrahim
Department of Paediatrics, Aminu Kano Teaching Hospital, Bayero University, Kano
Nigeria

Abstract

Background: Obstructive sleep apnea in children may be associated with cardiovascular complications and these may be identifiable on the electrocardiogram. Some of those changes seen in adults include ventricular hypertrophy and arrhythmias; however the exact prevalence of these in children is not known. Therefore, this study seeks to characterize the electrocardiographic features in children with obstructive sleep apnea. Materials and Methods: This study reviewed 43 electrocardiograms (ECGs) of children clinically diagnosed with obstructive sleep apnea (OSAS) aged 4-14 years; their ECG parameters were compared with 43 apparently healthy controls matched for age and sex. Results: There were 21 males and 22 females with male to female ratio of 1:1. The PR interval and QRS duration were higher in the obstructive sleep apnea group in the 4-9-year age group except for the QRS and P-wave axes. While in the 10-14-year-old age group lower values in the QRS axis, PR interval, QRS duration, and T-wave axis were recorded in those with obstructive sleep apnea; however, these were not statistically significant. The mean R- and S-waves amplitude in V 4 R, V 2 , V 5 and V 6 though higher in the obstructive sleep apnea group, but were not statistically significant. Premature ventricular complex was identified in only one of the subjects, phasic sinus arrhythmia in three of the subjects, and two ECGs had premature junctional complexes. T-wave inversion involving precordial leads V 4 R to V 3 was most predominant in all the age groups Conclusion: The ECG characteristics of children with OSAS in this study were comparable to previous report in children and the prevalence of arrhythmia was also low.



How to cite this article:
Ibrahim A, Ahmed A. Electrocardiographic characteristics of children with obstructive sleep apnea in a tertiary health center in Kano.Nig J Cardiol 2015;12:23-26


How to cite this URL:
Ibrahim A, Ahmed A. Electrocardiographic characteristics of children with obstructive sleep apnea in a tertiary health center in Kano. Nig J Cardiol [serial online] 2015 [cited 2022 Sep 25 ];12:23-26
Available from: https://www.nigjcardiol.org/text.asp?2015/12/1/23/148482


Full Text

 INTRODUCTION



Children are prone to upper respiratory tract infection (URI) - especially tonsillar, pharyngeal infections - and may have up to 6-8 episodes in a year. [1],[2],[3],[4]

Obstructive complication following URI may set in especially in those with concomitant craniofacial defects resulting in narrowing of the upper airway. These problems are most manifested during sleep resulting in sleep-disordered breathing such as snoring and obstructive sleep apnea [5] (OSAS); these at times, requiring tonsillectomy and adeno-tonsillectomy. [6],[7]

The gold standard for diagnosing OSAS is overnight polysomnography in a sleep laboratory which is scarce in most developing countries; therefore diagnosis in such settings is mostly clinical.

Airway obstruction may occasionally result in severe hypoxemia leading to cardiovascular complications such as arrhythmias, systemic and pulmonary hypertension, and right ventricular hypertrophy [8],[9] and these changes may manifest on the electrocardiogram (ECG). This communication therefore seeks to review the ECG of children who had tonsillectomy/adeno-tonsillectomy due to OSAS over a two-year period between January 2009 and December 2010 to determine their characteristics and presence of arrhythmias.

 MATERIALS AND METHODS



In a retrospective descriptive study, the ECGs of children aged 4-14 years prepared for tonsillectomy and adeno-tonsillectomy for OSAS at our center between January 2009 and December 2010 were reviewed. [10]

Information extracted from the case notes included: Age, gender, and ECG characteristics. Owing to the absence of generally accepted ECG reference standards among Nigerian children, their ECG characteristics were matched with those of apparently healthy children of the same age and gender seen in the Pediatrics Outpatient Department during well 'child follow-up visitation' over 6-week period between May and June 2014. The subjects were classified into two age groups: 4-9 years and 10-14 years.

Ethical approval was obtained from the Ethics Committee of Aminu Kano Teaching Hospital, Kano; while informed written consent was obtained from caregivers/parents of subjects in the control group. Patients with other co-morbidities such as congenital heart disease, sickle cell anemia, and with incomplete case records were excluded. For the control group, those who declined consent were excluded. ECG characteristics of 43 out of 67 children who had adeno-tonsillectomy were used in this study (24 of the ECGs were excluded because the subjects had other co-morbidities such as sickle cell anemia, congenital, and acquired heart diseases).

The ECG machine used for this study was a portable heated stylus direct writing AT-2 Swiss made electrocardiograph (Schiller AG cardiovit CH6341) with a frequency of 150 Hz and sampling frequency of 1000 Hz, with speeds of 25 mm/sec and 50 mm/sec, and three levels of sensitivity at 5, 10, and 20 mm/mV. Unipolar, bipolar limb leads, and chest leads with European color coding system were used. The 6-second method was used for heart rate calculation, the hex-axial method was used for the axes calculation and the clearest leads were used for interpretation. All measurements and interpretations were done manually by the authors with the aid of caliper and magnifying glass.

 DATA ANALYSIS



Statistical Package for Social Sciences (SPSS for Windows, version 19) software was used to analyze this data. Summary statistics such as frequency, mean, and standard deviation were employed while mean values were compared using student's t-test with a P-value less than 0.05 set as statistically significant.

 RESULTS



Forty-three (64.1%) ECGs were analyzed among 67 patients who had adenoidectomy/tonsillectomy for OSAS. Of the 43 subjects, there were 22 females and 21 males with female to male ratio of 1:1 among the ECG reviewed and their ages ranged between 4 and 14 years. Similarly 43 ECGs were done among healthy controls with 22 females and 21 males and female:male ratio of 1:1; their ages ranged between 4 and 14 years. [Table 1] shows that the differences of the mean ages of both study groups were not statistically significant for both the age groups (t = 0.285, P = 0.78 for the 4-9 years age group; t = 0.813, P = 0.42 for the 10-14 years age group).{Table 1}

Most of the ECG variables were higher in those with OSAS especially in the 4-9-year-old group except for the QRS and P-wave axes. While in the 10-14-year-old age group lower values in the QRS axis, PR interval, QRS duration, and T-wave axis were recorded in those with obstructive apnea; however, these differences were not statistically significant (P = 0.53, P = 0.81, P = 0.25, and P = 0.40, respectively) [Table 2] .{Table 2}

The mean R/S ratio on the right precordial lead V 4 R was less than 1 in all the study groups, while the mean R amplitude in V 4 R, V 2 , V 5 and V 6 though higher in the OSAS group, these differences were not statistically significant. Similarly the mean S-waves amplitude in V 4 R, V 2 , V 5 , and V 6 were higher in the OSAS group but these were not statistically significant [Table 3] and [Table 4].{Table 3}{Table 4}

Premature ventricular complex was identified in only one of the subjects, phasic sinus arrhythmia in three of the subjects, and two ECGs had premature junctional complexes.

T-wave inversion involving precordial leads V 4 R to V 3 was most predominate in all the age groups [Table 5] and [Figure 1].{Figure 1}{Table 5}

 DISCUSSION



The exact prevalence of OSAS is not known worldwide. However, some reports have quoted 1-4%; [11] this difficulty has been attributed to variations in the modality of diagnosing OSAS especially in different settings where the gold standard for ascertaining diagnosis is lacking. Diagnosis based purely on history, clinically examination, audiotaping, and videotaping has appreciable sensitivity and specificity; and has been found to be of immense importance in resource limited settings. [12]

Recurrent hypoxia or long-standing hypoxia from chronic upper airway obstruction may be associated with cardiovascular complications. Both ventricles of the heart may be affected resulting to ventricular hypertrophy, cor pulmonale, and in severe cases in heart failure. [13] These changes may manifest on the ECG; the mean ECG values for most of the variables such as the R-waves, S-waves though higher in those with OSAS when compared with the control subjects; but were not statistically significant.

The exact mechanism of arrhythmias in OSAS is not completely understood, some attribute it to the influence of hypoxia; continued inspiratory effort through a closed upper airway resulting in arousal and termination of sleep. These result in release of hormonal, neuro-endocrines secretions such as leptin, growth hormone, catecholamine resulting in increased risk of arrhythmia and these coupled with autonomic dysregulation. Which has negative impact on the heart and hemodynamic state predisposes to arrhythmia formation. [14] It occurs mostly during episodes of sleep, therefore they may not manifest during the wakeful state.

Cardiac arrhythmias have been reported in about 30%-50% of adult patients with OSAS and it occurs mostly during episodes of apnea. [14] Associated structural heart diseases further worsen the risk of arrhythmias. [15] Arrhythmias such as brady-arrhythmia, tachyarrhythmia, and atrial fibrillation [16],[17] have been reported in OSAS, though the exact prevalence in children is unknown; [18],[19] however, this study recorded only a case of premature ventricular complex, two of premature junctional complexes and three cases of phasic sinus arrhythmia-which is considered a normal variant. Furthermore increased heart rate was observed in the OSAS group and statistical significance was recorded in the 10-14-year age group; these findings were similar to those of Khositseth et al. [20]

There was a significant difference in PR interval in the 4-9 years group with the OSAS group having longer PR interval. Therefore, there may be tendency toward heart block in children in the affected age group with OSAS. Presence of T-wave inversion was also documented in this report; however, the pattern was not different from previous reports among apparently healthy Nigerians. [21],[22],[23]

 CONCLUSION



The ECG characteristics of children with OSAS in this study were comparable to previous report in children and the prevalence of arrhythmia was also low.

References

1Oyejide CO, Osinusi K. Acute respiratory tract infection in children in Idikan Community, Ibadan, Nigeria: Severity, risk factors, and frequency of occurrence. Rev Infect Dis 1990;12 Suppl 8:S1042-6.
2Selwyn BJ. The epidemiology of acute respiratory tract infection in young children: Comparison of findings from several developing countries. Coordinated Data Group of BOSTID Researchers. Rev Infect Dis 1990;12 Suppl 8:S870-88.
3Hortal M, Benitez A, Contera M, Etorena P, Montano A, Meny M. A community-based study of acute respiratory tract infections in children in Uruguay. Rev Infect Dis 1990;12 Suppl 8:S966-73.
4Thompson M, Vodicka TA, Blair PS, Buckley DI, Heneghan C, Hay AD; TARGET Programme Team. Duration of symptoms of respiratory tract infections in children. Systematic review. BMJ 2013;347:f7027.
5Chan J, Edman JC, Koltai PJ. Obstructive sleep apnea in children. Am Fam Physician 2004;69:1147-55.
6Goldstein NA, Stewart MG, Witsell DL, Hannley MT, Weaver EM, Yueh B, et al. TO TREAT Study Investigators. Quality of life after tonsillectomy in children with recurrent tonsillitis. Otolaryngol Head Neck Surg 2008;138 (1 Suppl):S9-S16.
7Singer LP, Saenger P. Complications of pediatric obstructive sleep apnea. Otolaryngol Clin North Am 1990;23:665-76.
8Bhattacharjee R, Kheirandish-Gozal L, Pillar G, Gozal D. Cardiovascular complications of obstructive sleep apnea syndrome: Evidence from children. Prog Cardiovasc Dis 2009;51:416-33.
9Schroeder BM; American Academy of Pediatrics. Obstructive sleep apnea syndrome in children. Am Fam Physician 2002;66:1338,43-4.
10Ahmed AO, Aliyu I, Kolo ES. Indications for tonsillectomy and adenoidectomy: Our experience. Niger J Clin Pract 2014;17:90-4.
11Ali NJ, Pitson DJ, Stradling JR. Snoring, sleep disturbance, and behaviour in 4-5 year olds. Arch Dis Child 1993;68:360-6.
12Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med 1999;131:485-91.
13Narkiewicz K, van de Borne PJ, Pesek CA, Dyken ME, Montano N, Somers VK. Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 1999;99:1183-9.
14Kaneko Y, Floras JS, Usui K, Plante J, Tkacova R, Kubo T, et al. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med 2003;348:1233-41.
15Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, et al. American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology; American Heart Association Stroke Council; American Heart Association Council on Cardiovascular Nursing; American College of Cardiology Foundation. Sleep apnea and cardiovascular disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 2008;118:1080-111.
16Grimm W, Hoffmann J, Menz V, Kohler U, Heitmann J, Peter JH, et al. Electrophysiologic evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea. Am J Cardiol 1996;77:1310-4.
17Gami AS, Pressman G, Caples SM, Kanagala R, Gard JJ, Davison DE, et al. Association of atrial fibrillation and obstructive sleep apnea. Circulation 2004;110:364-7.
18Fuster V, Ryden LE, Asinger RW, Cannom DS, Crijns HJ, Frye RL, et al. American College of Cardiology/American Heart Association Task Force on Practice Guidelines; European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation); North American Society of Pacing and Electrophysiology. ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: Executive summary; A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation) developed in collaboration with the North American Society of Pacing and Electrophysiology. Circulation 2001;104:2118-50.
19Quan SF, Gersh BJ; National Center on Sleep Disorders Research; National Heart, Lung, and Blood Institute. Cardiovascular consequences of sleep-disordered breathing: Past, present and future: Report of a workshop from the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute. Circulation 2004;109:951-7.
20Khositseth A, Chokechuleekorn J, Kuptanon T, Leejakpai A. Rhythm disturbances in childhood obstructive sleep apnea during apnea-hypopnea episodes. Ann Pediatr Cardiol 2013;6:39-42.
21Edemeka DB, Ojo GO. Electrocardiogram in Nigerian children. Saudi Heart J 1996;7:44-8.
22Aroaye MA. Morphological classification of ST-T waveforms in the ECGs of healthy adult Nigerians. West African Journal of Medicine 1983;2:117-25.
23Seriki O, Smith AJ. The electrocardiogram of young Nigerians. Am Heart J 1966;72:153-7.