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Year : 2019  |  Volume : 16  |  Issue : 1  |  Page : 25-31

Serum chemerin as a predictor of left ventricle hypertrophy in patients with coronary artery disease

1 Department of Cardiovascular Diseases, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Prof. Noha Hasssanin Hanboly
Department of Cardiovascular Diseases, Cairo University, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njc.njc_20_18

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Background: Left ventricular hypertrophy (LVH) is an important predictor of cardiovascular risk and its detection contributes to risk stratification. Chemerin is a secreted protein with a complex but well-established role in immune function. It regulates adipocyte development and metabolic function as well as glucose metabolism in liver and skeletal muscle tissues. Purpose of the Study: The aim of the current study was to investigate the correlation between the serum chemerin level and occurrence of LVH in patients with coronary artery disease (CAD). Patients and Methods: The study included 100 patients with CAD. Patients were classified according to their body mass index (BMI) into two groups, 50 patients (Group A) with BMI (≥30 kg/m2) and 50 patients (Group B) with BMI ≤25 kg/m2. Transthoracic echocardiography was done for all patients after a thorough clinical assessment. Left ventricular study was done according to the guidelines endorsed by the American society of echocardiography. Results: Serum chemerin level was positively correlated with BMI, waist circumference, and left ventricle mass index (P < 0.005 for all). Conclusion: Serum chemerin levels were higher in obese patients with CAD. Levels were associated with LVH and increased high-sensitivity C-reactive protein as a marker of inflammation.

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