Ischemia modified albumin in myocardial infarction and its correlation with selected acute phase reactants
Neepa Chowdhury1, Angshuman De2, Rabindra Bhattacharya3, Indranil Chakraborty4
1 Department of Biochemistry, Central Laboratory, Suraksha Diagnostic Private Limited, Saltlake, Kolkata, India
2 Department of Biochemistry, Murshidabad Medical College, Berhampore, Murshidabad, India
3 Department of General Medicine, College of Medicine and JNM Hospital, Kalyani, India
4 Department of Biochemistry, Malda Medical College and Hospital, Malda, West Bengal, India
Building Name Anamika, Flat No. 6, P-68, Subodh Park, P.S.+P.O. Bansdroni, Kolkata - 700 070, West Bengal
Source of Support: Department of Biochemistry, Medical College and Hospital, Kolkata, Department of Cardiology, Medical College and Hospital, Kolkata, Conflict of Interest: None
Background: There is evidence that ischemia modified albumin increases (IMA) in acute coronary syndrome, but enough work has not been done in assessing the correlation between IMA and inflammatory markers in myocardial infarction (MI).
Objective: The objective of the present study was to observe whether IMA would significantly be altered in MI patients and also whether the same would be correlated with selected acute phase reactants.
Methods: The present hospital based, noninterventional, cross-sectional study was undertaken in Medical College and Hospital, Kolkata. Fifty cases of acute MI (AMI) and 50 suitable controls were enrolled for the study. Serum IMA, serum albumin, serum total cholesterol, serum high-sensitivity C-reactive protein (hsCRP), serum ceruloplasmin and serum transferrin were measured in blood from the study population.
Results: Serum IMA and hsCRP (P < 0.0005) were significantly higher in cases whereas serum transferrin (P < 0.0005) and albumin (P < 0.005) were significantly lower in cases as compared to controls. In cases, IMA was found to be positively correlated (r = 0.470, P = 0.001) with hsCRP, one of the common markers of inflammation in AMI. Serum IMA, hsCRP and transferrin play a significant role (P < 0.05) in assessing the severity of inflammation.
Conclusion: Serum IMA was altered in AMI patients and positive correlation was obtained between IMA and positive acute phase reactant hsCRP. This study encourages future studies probing the role of inflammation in the causation of MI.