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ORIGINAL ARTICLE
Year : 2014  |  Volume : 11  |  Issue : 2  |  Page : 84-87

Prevalence and predictors of carotid artery atherosclerosis and its association with coronary artery disease in north Indian population


1 Department of General Medicine, Sher-i-Kashmir Institute of Medical Sciences, Soura Srinagar, Kashmir, India
2 Department of Pathology, Government Medical College, Jammu, Jammu and Kashmir, India
3 Department of Gastroenterology, ILBS, New Delhi, India

Correspondence Address:
Riyaz Ahmad Bhat
Flat F 18, Married Hostel, Sher i Kashmir Institute of Medical Sciences, Soura, Srinagar 190 011, Jammu and Kashmir
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0189-7969.142087

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Background: The reported prevalence of concomitant coronary and carotid atherosclerotic disease has varied among studies due to differences in study populations and methodologies used. Objectives: The purpose of the study was to know the prevalence of carotid atherosclerotic disease and to evaluate the relationship between coronary and carotid atherosclerotic disease. Materials and Methods: We performed a prospective study from December 2010 to November 2012 to determine the association of carotid artery stenosis (CAS) with documented coronary artery disease on Angiography in Kashmiri population. Continuous variables were expressed as mean ± SD. Two-sided unpaired "t"- test was performed for continuous variables and x 2 test for discrete variables. Multivariate stepwise logistic regression analysis was performed to detect independent predictors of CAS using factors that had significant relation in univariate analysis. A value of P ≤ 0.05 was considered statistically significant. Results: The study included 100 patients among whom 19.0% had significant carotid atherosclerotic stenosis (stenosis > 50%). The severity of carotid atherosclerotic stenosis and the carotid artery disease were significantly correlated (P = 0.001). The percentage of patients with three vessel involvements (42.1%) and significant carotid stenosis were more as compared with two vessels (31.6%) and one vessel involvement (21.1%). Independent predictors of significant CAS were the presence of left main descending carotid artery disease (31.3%), triple vessel carotid artery disease (17.8%), increasing age, a history of stroke or myocardial infarction (21.05%), smoking status (78.9%), diabetes mellitus (78.94%), and hypertension (78.94%). We did not find any significant correlation between carotid atherosclerotic stenosis and gender or degree of dyslipidemia. Conclusions: The degree of carotid atherosclerotic disease is related to the extent of coronary artery disease and important risk factors.


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