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ORIGINAL ARTICLE
Year : 2014  |  Volume : 11  |  Issue : 2  |  Page : 80-83

Serum levels of interleukin-17 in patients with and without acute coronary syndrome: A cross-sectional study in Babol, Northern Iran


1 Department of Cardiovascular Diseases, Babol University of Medical Sciences, Babol, Iran
2 Student Research Committee; Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
3 Cellular and Molecular Biology Research Center; Department of Immunology, Babol University of Medical Sciences, Babol, Iran
4 Student Research Committee, Babol University of Medical Sciences, Babol, Iran

Correspondence Address:
Mehrdad Saravi
Ayatollah Roohani Hospital, Babol University of Medical Sciences, Ganjafruz Street, Babol
Iran
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Source of Support: The Deputy of Research of Babol University of Medical Sciences for the financial support, Conflict of Interest: None


DOI: 10.4103/0189-7969.142086

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Background: The role of interleukin-17 (IL-17) in patients with acute coronary syndrome (ACS) is controversial. Objective: The aim of this study was to assess the serum level of IL-17 in patients with acute myocardial infarction (AMI) and unstable angina (UA) in Babol, Northern Iran in 2012. Materials and Methods: A total of 60 patients with ACS (30 with AMI, 30 with UA) and 30 healthy blood donors of Babol city, Iran were recruited in this cross-sectional study. Simple sampling method was used for patient selection. The inclusion criteria were the recent (<48 h) diagnosis of AMI or UA. The exclusion criteria were: Diagnosis of AMI or UA >48 h, recent history of infection or use of antibiotics. The serum IL-17 level was measured using enzyme-linked immunosorbent assay kit (Bioscience, Texas, USA). The lowest concentration of IL-17 that the kit could detect was 0.8 pg/ml. Chi-square, and Kruskal-Wallis tests were used for the comparison of IL-17 level between participants. P < 0.05 was considered as significant. Results: A total of 10 participants were excluded due to contaminated blood samples. Fifty (62.5%) were males and 30 (37.5%) were females. Four (13.3%) patients of AMI group and 1 (3.3%) of UA group had detectable levels of IL-17 (P = 0.353), but no one in blood donors (P = 0.114). There was also no significant association between the presence of detectable level of IL-17 and history of diabetes mellitus, hypertension, hyperlipidemia, smoking (P > 0.05). Conclusion: Our study did not find any significant differences in the serum level of IL-17 in individuals with or without ACS and therefore did not support the theory in which IL-17 has deleterious role in atherosclerosis.


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